Methadone Extraction by Modified QuEChERS and Liquid-Liquid Extraction from Post-Mortem Urine by GC-MS

QuEChERS stands for Quick, Easy, Cheap, Effective, Rugged, and Safe. This method is widely used to determine pesticides and was first introduced in 2003. Anastassiades and colleagues first introduced this method in 2003 to extract veterinary drugs from animal tissue [1]. Toxicology samples in forensic medicine are usually analyzed by Liquid-Liquid extraction (LLE) and solid phase extraction (SPE) methods. The SPE method is costly due to expensive cartridges and the cleaning of the homogenizer probe creates a risk of contamination and cross-reactivity, and therefore the SPE method is somewhat tedious and timeconsuming and cannot be performed in many centers, but the QuEChERS method is widely used as a simple, fast and reliable method is used [2]. An important step in the analysis of extraction toxicology samples is that Liquid-Liquid extraction and solid phase extraction are now used as methods for the pre-analysis of toxicology [3,4]. Preparation of the sample One of the critical steps in the correct diagnosis of a wide range of drugs and toxins by mass spectrometric chromatography (GC-MS) and liquid-mass spectrometry (LC-MS) chromatography [5,6]. Clinical toxicology and forensic medicine are heavily dependent on the science of decomposition chemistry [7,8]. Liquid-liquid extraction, in spite of its simplicity, reduces its value due to inadequate extraction of samples and contamination of tools and the environment. The SPE method with a high selective performance has less interference with LLE than the interfacing compounds, but this is relatively troublesome and time-consuming. The QuEChERS method was proposed for the analysis of legal toxicology [9]. The QuEChERS approach is similar to LLE for simplicity and also similar to SPE Volume 4 Issue 3 2017